I would believe it.

'And Eszterhas claims that when Madonna was trying to get the part in "Desperately Seeking Susan," she went to the office of Orion production chief Barbara Boyle, "dropped to her knees and said, 'I'll do anything to get this part.' Boyle said, 'I'm happily married and I'm straight,' to which Madonna replied, 'You should try everything once.'"

NY Daily News